Mosaku was born in Zaria, Nigeria, and subsequently emigrated to Manchester, England, where she attended Trinity Church of England High School and Xaverian Sixth Form College. She also sang for eleven years in the Manchester Girls Choir.
Mosaku graduated from RADA in 2007 and made her stage debut at the Arcola Theatre in a production of Pedro Calderón de la Barca's The Great Theatre of the World. Since then she has also appeared in Rough Crossings, directed by Rupert Goold and based on the book by Simon Schama, at the Lyric Hammersmith; The Vertical Hour by David Hare and Truth and Reconciliation, both at the Royal Court Theatre and Mules at the Young Vic. In 2009 she appeared in Katrina a verbatim play which told six people's stories of their struggles of survival when Hurricane Katrina devastated New Orleans August 2005. Mosaku was originally cast as Sophie in the UK premiere of Ruined by Lynn Nottage at the Almeida Theatre but had to pull out due to an injury.
In 2008, she appeared in the first of the UNDEREXPOSED exhibitions at the National Portrait Gallery designed to raise the profile of black role models and celebrates the talent that exists among the Black British community. Her photo also appeared on Commercial Way, Peckham, London, as part of the exhibition.
She featured on the front cover of Screen International magazine June–July 2009 as one of the UK Stars of Tomorrow, and in 2011 was featured in Nylon Magazine's 2011 Young Hollywood issue.
In 2010 Wunmi Mosaku was named one of The Seven Fresh Faces of Toronto International Film Festival, for I Am Slave, in which she starred. She plays Malia, a girl who has been kidnapped from her village in Sudan, and sold into slavery. For her performance Mosaku won awards such as Best Actress at the Birmingham Black Film Festival, Best Onscreen performance at the Cultural Diversity Awards and Best Female performance at the Screen Nation Awards.When asked to list her personal heroes, Mosaku included her grandmother Anike Adisa, whom she described as having "taught me so many lessons", actor Albert Finney who Mosaku said was her inspiration for attending the Royal Academy of Dramatic Art, her colleague and former instructor at RADA, William Gaskill, Paul Newman who she stated she admired not just for his acting but also for his philanthropic efforts withNewman's Own, and Oprah Winfrey who Mosaku said she considers "a superwoman
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